Endocrine Abstracts

Objectives: Atrial natriuretic peptide (ANP) is a cardiac hormone that is known to play an essential role in regulation of blood pressure and vascular endothelial function. However, the metabolic regulation of ANP is not fully understood. In patients suffering from metabolic syndrome hypertension, hyperinsulinemia and postprandial hyperglucagonemia are common features. It was the aim of the present study to evaluate the impact of glucagon on proANP and the possible mechanisms ...

Objectives: Gastrointestinal hormones are known to modulate satiety. The mechanisms underlying the impact of glucagon on satiety are so far unknown. However, it can be postulated that the glucagon-induced reduction in hunger feeling is mediated through changes in Cholecystokinin (CCK), which is known to play a role in meal termination. It was the aim of the present study to evaluate the impact of glucagon on CCK and the modulation of these effects in obesity.<p class="abst...

Objective: The mechanisms underlying the well known glucagon-induced satiety effect are unclear. As we showed recently, the glucagon-induced reduction in total ghrelin, that might be responsible for this effect, is exerted at hypothalamus–pituitary level. The aim of the present study was to further evaluate glucagon’s suppressive effect on both total and acylated-ghrelin in obesity with respect to its role in appetite control.Methods: Prospecti...